منابع مشابه
Protein deacetylases and axonal regeneration
A neuron with injured or severed axon responds with attempts at axonal regrowth. In this regard, axonal regeneration of peripheral nerves occurs far more efficiently compared to central nervous system (CNS) neurons. The latter typically could not form a proper growth cone, and any axonal regeneration in vivo is very limited. The adult CNS environment is not conducive for axonal regrowth. An ext...
متن کاملInhibition of Axonal Regeneration*
Because axonal damage and loss are frequent phenomena of multiple sclerosis and other types of neurodegenerative diseases, and because the effects can be devastating clinically, attention has been focused on repair to axons. However, axon regeneration appears to be inhibited via a variety of possible cellular pathways and molecules. In the following article, several of these pathways are examin...
متن کاملIntegrins promote axonal regeneration after injury of the nervous system: Integrins and axonal regeneration
Integrins are cell surface receptors that form the link between extracellular matrix molecules of the cell environment and internal cell signalling and the cytoskeleton. They are involved in several processes, e.g. adhesion and migration during development and repair. This review focuses on the role of integrins in axonal regeneration. Integrins participate in spontaneous axonal regeneration in...
متن کاملTransplantation of Olfactory Mucosa Improve Functional Recovery and Axonal Regeneration Following Sciatic Nerve Repair in Rats
Background: Olfactory ensheathing glia (OEG) has been shown to have a neuroprotective effect after being transplanted in rats with spinal cord injury. This study was conducted to determine the possible beneficial results of olfactory mucosa transplantation (OMT) which is a source of OEG on functional recovery and axonal regeneration after transection of the sciatic nerve. Methods: In this study...
متن کاملRetinoic acid signaling in axonal regeneration
Following an acute central nervous system (CNS) injury, axonal regeneration and functional recovery are extremely limited. This is due to an extrinsic inhibitory growth environment and the lack of intrinsic growth competence. Retinoic acid (RA) signaling, essential in developmental dorsoventral patterning and specification of spinal motor neurons, has been shown through its receptor, the transc...
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ژورنال
عنوان ژورنال: Neural Regeneration Research
سال: 2019
ISSN: 1673-5374
DOI: 10.4103/1673-5374.247422